PFIZER SOLVENT SELECTION GUIDE



Pfizer Solvent Selection Guide

Tools and techniques for solvent selection green solvent. Pfizer developed an educational tool in the form of an electronic in-house Reagent Selection guide for use by medicinal chemists to assess greenness of their chemistry. This tool provides rapidly accessible information to select efficient green transformations by grading reagents using three criteria: greenness, utility and scalability, and is visually represented in the form of Venn …, GSK published the first SSG in 1999 and Pfizer was the first to employ traffic light inspired colour coding to categorize solvents as green, V.L. CunninghamExpanding GSK's solvent selection guide—application of life cycle assessment to enhance solvent selections. Clean Technol Environ Policy, 7 (2005), pp. 42-50..

Supplementary Material (ESI) for Green Chemistry This

The greening of solvents Towards sustainable organic. Amgen AstraZeneca Novartis Pfizer/ Wyeth GSK Abbott Genzyme 31 23 19 18 18 15 7 3 * As of October 2010. For molecules with multiple indications, phase of lead indication was counted . Solvent Selection Guide 29. A ‘use this instead’, rather than ‘don’t use’ philosophy., of publicly available information by the ACS GCI Pharmaceutical Roundtable. Comments may be sent to gcipr@acs.org. No warranty is made and all warranties are expressly disclaimed. The guide has been developed considering safety, health, environment aspects of solvent selection. Other aspects may need to be considered in process design..

20-12-2013 · Sanofi’s solvent selection guide helps chemists in early development select sustainable solvents that will be accepted in all production sites. Solvents are divided into four classes, from “recommended” to “banned”. This ranking is derived from Safety, Health, Environmental, Quality, and Industrial constraints. Each solvent has its own ID card that … Pfizer Green Chemistry Results Some Examples Combined Groton, Sandwich and La Jolla DCM use 2004 - 2007 120.4 93.5 DCM use per year in tonnes 58.0 51.7 Year 8 Pfizer Solvent Switching Program. PGRD Global Diisopropylether Use ; 9 Reagent Selection Guide. 10 Reagent Selection Guide. 11 Example Oxidation of Primary Alcohol to Aldehyde. PCC PDC. CrO3

Green chemistry solvent selection guide success. Posted on 13 August 2018. A solvent selection guide developed in collaboration with York’s Green Chemistry Centre of Excellence has been adopted by the ACS Green Chemistry Institute. as Pfizer, Merck, Bristol-Myers Squibb, Eli Lily, Sanofi, to name few, have combined and leveraged their collective expertise of using Green and Sustainable chemistry and engineering principles towards developing many tools like the solvent selection guide, the …

ACS GCI Pharmaceutical Roundtable Moving towards Greener Solvents for Pharmaceutical Manufacturing - An Industry Perspective Peter Dunn (Pfizer), Richard Henderson (GlaxoSmithKline), Ingrid Mergelsberg (Schering-Plough) & Andrew Wells (AstraZeneca) Website: Roundtable to publicize the ACS GCIPR Solvent Selection Guide Green chemistry solvent selection guide success. Posted on 13 August 2018. A solvent selection guide developed in collaboration with York’s Green Chemistry Centre of Excellence has been adopted by the ACS Green Chemistry Institute.

of publicly available information by the ACS GCI Pharmaceutical Roundtable. Comments may be sent to gcipr@acs.org. No warranty is made and all warranties are expressly disclaimed. The guide has been developed considering safety, health, environment aspects of solvent selection. Other aspects may need to be considered in process design. CHEM21 selection guide of classical- and less classical-solvents† Denis Prat,*a Andy Wells,b John Hayler,c Helen Sneddon,c C. Robert McElroy,d Sarah Abou-Shehadad and Peter J. Dunne A selection guide of common solvents has been elaborated, based on a survey of publically available solvent selection guides.

Green Chemistry, Biocatalysis and Environmental Assessment 1 Pfizer Green Chemistry Tools 5 Solvent Guides – simple, more detailed Biocatalysis Guide Simple Solvent Selection Guide Preferred Water Acetone Ethanol 2-Propanol 1-Propanol Ethyl Acetate Tools and techniques for solvent selection: Green solvent selection Solvent selection guide, Bio-based solvent, organic solvents in the Pfizer and Sanofi selection guides for

CHEM21 Solvent Selection Guide Denis PRAT, Process Safety & Environment Chemistry & Biochemistry Sanofi Chimie, Gentilly (France) 4th Industrial Green Chemistry World Conference, Mumbai, 05 December 2015 6-9-2018 · A solvent selection guide developed in collaboration with researchers from York’s Green Chemistry Centre of Excellence has been adopted by the ACS Green Chemistry Institute, a world leader in green chemistry education, as their recommended method of selecting more environmentally friendly solvents.

Table Selection an overview ScienceDirect Topics. In-house solvent selection guides A large number of solvent selection guides are available in the literature and have been developed in-house by a number of pharmaceutical companies including GlaxoSmithKline, Pfizer (who have also produced a freely-available printable poster), Sanofi and Astra Zeneca. [1] [2] [3] [4]., Article frm 2016 about green solvent selection.

Pfizer reagent selection guide Reagent guides CHEM21

pfizer solvent selection guide

Green chemistry tools to influence a medicinal chemistry. Green Chemistry, Biocatalysis and Environmental Assessment 1 Pfizer Green Chemistry Tools 5 Solvent Guides – simple, more detailed Biocatalysis Guide Simple Solvent Selection Guide Preferred Water Acetone Ethanol 2-Propanol 1-Propanol Ethyl Acetate, 60 members of the Pfizer Green Chemistry teams To our partners in education and research To YOU – today’s audience! Pfizer GC Solvent Guide Reagent Guide has been published P.J. Dunn and D.A. Perry et al. Green Chemistry, 2008, 9, 31-36..

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pfizer solvent selection guide

Green chemistry solvent selection guide success. 23-5-2016 · As an accompaniment to the Pfizer solvent selection guide, a useful substitution guide is provided for those solvents regarded as undesirable (Table 3). In this accompanying tool they suggest DCM as a replacement for other chlorinated solvents in cases when a non-chlorinated solvent is not applicable. https://en.wikipedia.org/wiki/E._J._Corey 15-4-2016 · A selection guide of common solvents has been elaborated, based on a survey of publically available solvent selection guides. In order to rank less classical solvents, a set of Safety, Health and Environment criteria is proposed, aligned with the Global Harmonized System (GHS) and European regulations..

pfizer solvent selection guide

  • ACS GCI Pharmaceutical Roundtable
  • Green Chemistry at Pfizer DBU
  • Solvents and sustainable chemistry PubMed Central (PMC)
  • Niklaus Stoecklin (1896-1982 Basel) Chemiebild Die

  • Supplementary Material (ESI) for Green Chemistry GSK Solvent Selection Guide 2009 Classification Solvent CAS number Melting point °C Boiling point °C Waste Stabilityrecycling, incineration, VOC, and biotreatment issues Environmental Impact fate and effects on … Several solvent selection guides have been published by pharmaceutical companies or institutions (Pfizer, GSK, GCI-PR, and Sanofi). A special focus on Sanofi’s guide will be made. As part of the European project CHEM21, a survey of these solvent guides has been made, permitting to rank many classical solvents into four categories, from "recommended" to "highly hazardous".

    Fig. 1 Pfizer solvent selection guide for medicinal chemistry. A summary of why each solvent is placed in the red category is provided in Table 1 Table 1 Red category solvents Red solvent Flash point Reason Pentane –49 °C Very low flash point, good alternative available. In-house solvent selection guides A large number of solvent selection guides are available in the literature and have been developed in-house by a number of pharmaceutical companies including GlaxoSmithKline, Pfizer (who have also produced a freely-available printable poster), Sanofi and Astra Zeneca. [1] [2] [3] [4].

    Pfizer is finding innovative ways to minimize our impact on the environment during the manufacturing of pharmaceuticals and is continuously "greening" the process. In particular, we leverage our Green Chemistry and Biotechnology program to advance scientific innovation – our core strength – to help develop processes that are more sustainable, environmentally sound and Green chemistry, also called sustainable chemistry, is an area of chemistry and chemical engineering focused on the designing of products and processes that minimize or eliminate the use and generation of hazardous substances. While environmental chemistry focuses on the effects of polluting chemicals on nature, green chemistry focuses on the environmental impact …

    CHEM21 Solvent Selection Guide Denis PRAT, Process Safety & Environment Chemistry & Biochemistry Sanofi Chimie, Gentilly (France) 4th Industrial Green Chemistry World Conference, Mumbai, 05 December 2015 Günter Jagschies, Karol M. Łącki, in Biopharmaceutical Processing, 2018. 4.5.2 Downstream Processing Yield and Scale Requirements. The product yielded upstream, once harvested, needs to be processed within a limited time, often within 24 h or less, mainly due to stability reasons.

    Article frm 2016 about green solvent selection ACS GCI Pharmaceutical Roundtable Moving towards Greener Solvents for Pharmaceutical Manufacturing - An Industry Perspective Peter Dunn (Pfizer), Richard Henderson (GlaxoSmithKline), Ingrid Mergelsberg (Schering-Plough) & Andrew Wells (AstraZeneca) Website: Roundtable to publicize the ACS GCIPR Solvent Selection Guide

    Green Chemistry at Pfizer DBU

    pfizer solvent selection guide

    CHEM21 Solvent Selection Guide Industrial Green Chemistry. ACS GCI Pharmaceutical Roundtable Collaboration to Deliver a Solvent Selection Guide for the Pharmaceutical Industry Caireen R. Hargreaves, AstraZeneca Pfizer Medicinal Chemistry Solvent Selection Guide. Preferred Water Acetone Ethanol 2-Propanol 1-Propanol Ethyl Acetate, Green Chemistry Initiative Solvent and Reagent Selection Guides. Green Chemistry Organizations and Student Groups . Reaction Evaluation Tools. Educational Resources. Recommended Journals. Green Chemistry Blogs.

    Niklaus Stoecklin (1896-1982 Basel) Chemiebild Die

    Solvent Use and Waste Issues Green Chemistry in the. 15-4-2016 · A selection guide of common solvents has been elaborated, based on a survey of publically available solvent selection guides. In order to rank less classical solvents, a set of Safety, Health and Environment criteria is proposed, aligned with the Global Harmonized System (GHS) and European regulations., Toward a More Holistic Framework for Solvent Selection. Louis J the ACS GCIPR has developed a solvent guide based on approaches and data provided by AstraZeneca and Pfizer. This comprises a detailed guide with five The new GSK solvent selection guide enables GSK scientists to objectively assess solvents and det. whether existing.

    Supplementary Material (ESI) for Green Chemistry GSK Solvent Selection Guide 2009 Classification Solvent CAS number Melting point °C Boiling point °C Waste Stabilityrecycling, incineration, VOC, and biotreatment issues Environmental Impact fate and effects on … Expanding GSK's Solvent Selection Guide – Embedding sustainability into solvent selection starting at Medicinal Chemistry. Pfizer [4], and Sanofi [5

    Green Solvents 13 GENESIS OF SANOFI’S SOLVENT GUIDE We did not have a common vision of the preferred solvents Sanofi-Synthelabo-Hoechst-Marion-Roussel-Rhone-Poulenc-Rorer Research vs Production Working group created in 2009 Reshaping of former HSE guide Integration of industrial constraints Integration of GHS/ CLP Constraints: Increasing difficulties to change the … Case Study-Pfizer Pharmaceuticals- Green Chemistry Innovation and Business Strategy.pdf. Pfizer Pharmaceuticals. ACS GCI Pharmaceutical Roundtable Solvent Selection Guide.pdf. ACS GCI Pharmaceutical Roundtable Solvent Selection Guide. Design Principles for Sustainable Green Chemistry & Engineering.pdf.

    CHEM21 Solvent Selection Guide Denis PRAT, Process Safety & Environment Chemistry & Biochemistry Sanofi Chimie, Gentilly (France) 4th Industrial Green Chemistry World Conference, Mumbai, 05 December 2015 Green Solvents 13 GENESIS OF SANOFI’S SOLVENT GUIDE We did not have a common vision of the preferred solvents Sanofi-Synthelabo-Hoechst-Marion-Roussel-Rhone-Poulenc-Rorer Research vs Production Working group created in 2009 Reshaping of former HSE guide Integration of industrial constraints Integration of GHS/ CLP Constraints: Increasing difficulties to change the …

    Green Chemistry, Biocatalysis and Environmental Assessment 1 Pfizer Green Chemistry Tools 5 Solvent Guides – simple, more detailed Biocatalysis Guide Simple Solvent Selection Guide Preferred Water Acetone Ethanol 2-Propanol 1-Propanol Ethyl Acetate Green Solvents 13 GENESIS OF SANOFI’S SOLVENT GUIDE We did not have a common vision of the preferred solvents Sanofi-Synthelabo-Hoechst-Marion-Roussel-Rhone-Poulenc-Rorer Research vs Production Working group created in 2009 Reshaping of former HSE guide Integration of industrial constraints Integration of GHS/ CLP Constraints: Increasing difficulties to change the …

    Article frm 2016 about green solvent selection 60 members of the Pfizer Green Chemistry teams To our partners in education and research To YOU – today’s audience! Pfizer GC Solvent Guide Reagent Guide has been published P.J. Dunn and D.A. Perry et al. Green Chemistry, 2008, 9, 31-36.

    Fig. 1 Pfizer solvent selection guide for medicinal chemistry. A summary of why each solvent is placed in the red category is provided in Table 1 Table 1 Red category solvents Red solvent Flash point Reason Pentane –49 °C Very low flash point, good alternative available. Expanding GSK's Solvent Selection Guide – Embedding sustainability into solvent selection starting at Medicinal Chemistry. Pfizer [4], and Sanofi [5

    Part of the role of the process systems engineer is to utilize the data on solvents and make selection decisions based on the application and function. This can be done working directly with the data, using a computer algorithm to guide the decisions, or using a heuristic model for benchmarking the solvent. ACS GCI Pharmaceutical Roundtable Collaboration to Deliver a Solvent Selection Guide for the Pharmaceutical Industry Caireen R. Hargreaves, AstraZeneca Pfizer Medicinal Chemistry Solvent Selection Guide. Preferred Water Acetone Ethanol 2-Propanol 1-Propanol Ethyl Acetate

    Pfizer Green Chemistry Results Some Examples Combined Groton, Sandwich and La Jolla DCM use 2004 - 2007 120.4 93.5 DCM use per year in tonnes 58.0 51.7 Year 8 Pfizer Solvent Switching Program. PGRD Global Diisopropylether Use ; 9 Reagent Selection Guide. 10 Reagent Selection Guide. 11 Example Oxidation of Primary Alcohol to Aldehyde. PCC PDC. CrO3 Pfizer Green Chemistry Results Some Examples Combined Groton, Sandwich and La Jolla DCM use 2004 - 2007 120.4 93.5 DCM use per year in tonnes 58.0 51.7 Year 8 Pfizer Solvent Switching Program. PGRD Global Diisopropylether Use ; 9 Reagent Selection Guide. 10 Reagent Selection Guide. 11 Example Oxidation of Primary Alcohol to Aldehyde. PCC PDC. CrO3

    20-12-2013 · Sanofi’s solvent selection guide helps chemists in early development select sustainable solvents that will be accepted in all production sites. Solvents are divided into four classes, from “recommended” to “banned”. This ranking is derived from Safety, Health, Environmental, Quality, and Industrial constraints. Each solvent has its own ID card that … Solvent Selection Guide ‌ Solvents constitute the bulk of the materials used in the production of fine chemical and pharmaceutical products. Therefore, to limit the environmental impact of these products, solvent selection is paramount in reaction and process design and although many solvent selection guides are already in existence, there are many discrepancies between them …

    Green Solvents 13 GENESIS OF SANOFI’S SOLVENT GUIDE We did not have a common vision of the preferred solvents Sanofi-Synthelabo-Hoechst-Marion-Roussel-Rhone-Poulenc-Rorer Research vs Production Working group created in 2009 Reshaping of former HSE guide Integration of industrial constraints Integration of GHS/ CLP Constraints: Increasing difficulties to change the … Pfizer developed an educational tool in the form of an electronic in-house Reagent Selection guide for use by medicinal chemists to assess greenness of their chemistry. This tool provides rapidly accessible information to select efficient green transformations by grading reagents using three criteria: greenness, utility and scalability, and is visually represented in the form of Venn …

    6-9-2018 · A solvent selection guide developed in collaboration with researchers from York’s Green Chemistry Centre of Excellence has been adopted by the ACS Green Chemistry Institute, a world leader in green chemistry education, as their recommended method of selecting more environmentally friendly solvents. Fig. 1 Pfizer solvent selection guide for medicinal chemistry. A summary of why each solvent is placed in the red category is provided in Table 1 Table 1 Red category solvents Red solvent Flash point Reason Pentane –49 °C Very low flash point, good alternative available.

    20-12-2013 · Sanofi’s solvent selection guide helps chemists in early development select sustainable solvents that will be accepted in all production sites. Solvents are divided into four classes, from “recommended” to “banned”. This ranking is derived from Safety, Health, Environmental, Quality, and Industrial constraints. Each solvent has its own ID card that … CHEM21 Researchers then went on to develop a CHEM21 solvent selection guide to unify the surveyed solvent selection guides, as well as come to a clear assignment for those solvents that did not correlate well across the four guides.

    Selection of Green Solvents. 13-12-2010 · The new GSK solvent selection guide enables GSK scientists to objectively assess solvents and determine whether existing or new solvents brought to market as ‘greener’ alternatives truly represent a more sustainable choice or whether they are just addressing a single issue associated with sustainability., The Good, the Bad and the Ugly A guide to solvent selection Usable Cylcohexane Heptane Toluene Methylcyclohexane Methyl t-butyl ether Isooctane Acetonitrile 2-MethylTHF Tetrahydrofuran Xylenes Dimethyl sulfoxide Acetic acid Ethylene glycol.

    (PDF) Expanding GSK's Solvent Selection Guide – Embedding

    pfizer solvent selection guide

    (PDF) Bio-Based Solvents for Organic Synthesis James. Pfizer Green Chemistry Results Some Examples Combined Groton, Sandwich and La Jolla DCM use 2004 - 2007 120.4 93.5 DCM use per year in tonnes 58.0 51.7 Year 8 Pfizer Solvent Switching Program. PGRD Global Diisopropylether Use ; 9 Reagent Selection Guide. 10 Reagent Selection Guide. 11 Example Oxidation of Primary Alcohol to Aldehyde. PCC PDC. CrO3, The Good, the Bad and the Ugly A guide to solvent selection Usable Cylcohexane Heptane Toluene Methylcyclohexane Methyl t-butyl ether Isooctane Acetonitrile 2-MethylTHF Tetrahydrofuran Xylenes Dimethyl sulfoxide Acetic acid Ethylene glycol.

    pfizer solvent selection guide

    Solvent Selection Guide Chemistry The University of York. ACS GCI Pharmaceutical Roundtable Collaboration to Deliver a Solvent Selection Guide for the Pharmaceutical Industry Caireen R. Hargreaves, AstraZeneca Pfizer Medicinal Chemistry Solvent Selection Guide. Preferred Water Acetone Ethanol 2-Propanol 1-Propanol Ethyl Acetate, Pfizer Green Chemistry Results Some Examples Combined Groton, Sandwich and La Jolla DCM use 2004 - 2007 120.4 93.5 DCM use per year in tonnes 58.0 51.7 Year 8 Pfizer Solvent Switching Program. PGRD Global Diisopropylether Use ; 9 Reagent Selection Guide. 10 Reagent Selection Guide. 11 Example Oxidation of Primary Alcohol to Aldehyde. PCC PDC. CrO3.

    Supplementary Material (ESI) for Green Chemistry This

    pfizer solvent selection guide

    (PDF) Tools and techniques for solvent selection Green. CHEM21 Solvent Selection Guide Denis PRAT, Process Safety & Environment Chemistry & Biochemistry Sanofi Chimie, Gentilly (France) 4th Industrial Green Chemistry World Conference, Mumbai, 05 December 2015 https://en.wikipedia.org/wiki/Dow_Chemical_Company Article frm 2016 about green solvent selection.

    pfizer solvent selection guide


    Green Chemistry, Biocatalysis and Environmental Assessment 1 Pfizer Green Chemistry Tools 5 Solvent Guides – simple, more detailed Biocatalysis Guide Simple Solvent Selection Guide Preferred Water Acetone Ethanol 2-Propanol 1-Propanol Ethyl Acetate Several solvent selection guides have been published by pharmaceutical companies or institutions (Pfizer, GSK, GCI-PR, and Sanofi). A special focus on Sanofi’s guide will be made. As part of the European project CHEM21, a survey of these solvent guides has been made, permitting to rank many classical solvents into four categories, from "recommended" to "highly hazardous".

    Article frm 2016 about green solvent selection In-house solvent selection guides A large number of solvent selection guides are available in the literature and have been developed in-house by a number of pharmaceutical companies including GlaxoSmithKline, Pfizer (who have also produced a freely-available printable poster), Sanofi and Astra Zeneca. [1] [2] [3] [4].

    Green Solvents 13 GENESIS OF SANOFI’S SOLVENT GUIDE We did not have a common vision of the preferred solvents Sanofi-Synthelabo-Hoechst-Marion-Roussel-Rhone-Poulenc-Rorer Research vs Production Working group created in 2009 Reshaping of former HSE guide Integration of industrial constraints Integration of GHS/ CLP Constraints: Increasing difficulties to change the … Article frm 2016 about green solvent selection

    Solvent Selection Guide. Choosing the right solvent is crucial to ensuring a more favorable sustainability profile of a batch chemical manufacturing process common to the pharmaceutical industry. In the pharmaceutical industry, more than 80% of materials used to manufacture bulk active pharmaceutical ingredients are solvents (including water). GSK published the first SSG in 1999 and Pfizer was the first to employ traffic light inspired colour coding to categorize solvents as green, V.L. CunninghamExpanding GSK's solvent selection guide—application of life cycle assessment to enhance solvent selections. Clean Technol Environ Policy, 7 (2005), pp. 42-50.

    In-house solvent selection guides A large number of solvent selection guides are available in the literature and have been developed in-house by a number of pharmaceutical companies including GlaxoSmithKline, Pfizer (who have also produced a freely-available printable poster), Sanofi and Astra Zeneca. [1] [2] [3] [4]. In Byrne et al., “Tools and Techniques for Solvent Selection: Green Solvent Selection Guides.” 11 GlaxoSmithKline (GSK) then published a simplified solvent selection guide for medicinal chemistry laboratories themselves, derived from an updated and expanded solvent assessment.

    of publicly available information by the ACS GCI Pharmaceutical Roundtable. Comments may be sent to gcipr@acs.org. No warranty is made and all warranties are expressly disclaimed. The guide has been developed considering safety, health, environment aspects of solvent selection. Other aspects may need to be considered in process design. In Byrne et al., “Tools and Techniques for Solvent Selection: Green Solvent Selection Guides.” 11 GlaxoSmithKline (GSK) then published a simplified solvent selection guide for medicinal chemistry laboratories themselves, derived from an updated and expanded solvent assessment.

    1-8-2007 · Influencing and improving the environmental performance of a large multi-national pharmaceutical company can be achieved with the help of electronic education tools, backed up by site champions and strong site teams. This paper describes the development of two of those education tools. CHEM21 Solvent Selection Guide Denis PRAT, Process Safety & Environment Chemistry & Biochemistry Sanofi Chimie, Gentilly (France) 4th Industrial Green Chemistry World Conference, Mumbai, 05 December 2015

    6-9-2018 · A solvent selection guide developed in collaboration with researchers from York’s Green Chemistry Centre of Excellence has been adopted by the ACS Green Chemistry Institute, a world leader in green chemistry education, as their recommended method of selecting more environmentally friendly solvents. Amgen AstraZeneca Novartis Pfizer/ Wyeth GSK Abbott Genzyme 31 23 19 18 18 15 7 3 * As of October 2010. For molecules with multiple indications, phase of lead indication was counted . Solvent Selection Guide 29. A ‘use this instead’, rather than ‘don’t use’ philosophy.

    Tools and techniques for solvent selection: Green solvent selection Solvent selection guide, Bio-based solvent, organic solvents in the Pfizer and Sanofi selection guides for Expanding GSK's Solvent Selection Guide – Embedding sustainability into solvent selection starting at Medicinal Chemistry. Pfizer [4], and Sanofi [5

    Green Solvents 13 GENESIS OF SANOFI’S SOLVENT GUIDE We did not have a common vision of the preferred solvents Sanofi-Synthelabo-Hoechst-Marion-Roussel-Rhone-Poulenc-Rorer Research vs Production Working group created in 2009 Reshaping of former HSE guide Integration of industrial constraints Integration of GHS/ CLP Constraints: Increasing difficulties to change the … Green Solvents 13 GENESIS OF SANOFI’S SOLVENT GUIDE We did not have a common vision of the preferred solvents Sanofi-Synthelabo-Hoechst-Marion-Roussel-Rhone-Poulenc-Rorer Research vs Production Working group created in 2009 Reshaping of former HSE guide Integration of industrial constraints Integration of GHS/ CLP Constraints: Increasing difficulties to change the …

    15-4-2016 · A selection guide of common solvents has been elaborated, based on a survey of publically available solvent selection guides. In order to rank less classical solvents, a set of Safety, Health and Environment criteria is proposed, aligned with the Global Harmonized System (GHS) and European regulations. This study focuses on the development of computational impurity purge factor to enable rational solvent selection for purification of pharmaceutical compounds via recrystallization. Three purge factors have been proposed under SLE thermodynamic consideration based on two properties: impurity partition coefficient between solvent and crystalline pharmaceutical, and …