PATHOPHYSIOLOGY OF SEPSIS PDF



Pathophysiology Of Sepsis Pdf

pathophysiology of sepsis LITFL. Nov 09, 2017 · This is video 1 of 2 on shock (the types of shock & shock treatment) and sepsis and is part of the "MedCram Remastered" series: A video we've re …, May 23, 2016 · Sepsis, severe sepsis, and septic shock represent increasingly severe systemic inflammatory responses to infection. Sepsis is common in the aging population, and it disproportionately affects patients with cancer and underlying immunosuppression. In its most severe form, sepsis causes multiple organ dysfunction that can produce a state of chronic critical illness characterized by severe ….

Surviving Sepsis Campaign The Pathophysiology of Sepsis

"The Pathophysiology of Sepsis" by Rachel Hamilton. May 26, 2016- Explore timfluenze's board "Pathophysiology Flowcharts" on Pinterest. See more ideas about Sepsis, Septic shock and Sepsis pathophysiology., Sepsis is still a leading cause of hospital admissions and often leads to death if not identified early and treated properly (Pilcher, Cooper & Bellomo, 2015). In the US there are approximately 200,000 deaths annually due to sepsis (Puskarich, Illich, & Jones, 2014). It is important for advance practice nurses to recognize risk factors for sepsis..

May 23, 2016 · Sepsis, severe sepsis, and septic shock represent increasingly severe systemic inflammatory responses to infection. Sepsis is common in the aging population, and it disproportionately affects patients with cancer and underlying immunosuppression. In its most severe form, sepsis causes multiple organ dysfunction that can produce a state of chronic critical illness characterized by severe … In this case study, the pathophysiology of sepsis will be discussed and the mechanism of synchronised intermittent mandatory ventilation (SIMV) volume control ventilation mode will be explained. Sepsis is defined as the dysregulated inflammatory response caused by severe infection (Neviere 2015).

Mortality rates for sepsis and septic shock have not improved in the past decade. The Surviving Sepsis Campaign (SSC) guidelines released in 2012 emphasize early recognition and treatment of sepsis, in an effort to reduce the burden of sepsis worldwide. Apr 05, 2019 · OVERVIEW Organisms Bacteria-> Gram +ve’ cocci (staphylococci, streptococci)-> Gram –ve bacilli (E.coli, Klebsiella, Pseudomonas aeruginosa) Fungi (Candida) Viruses Parasites Complex interaction between inciting microbe host immune response inflammatory pathway coagulation pathway LPS = lipopolysaccharideTRAF6 = TNF receptor-associated factor 6NIK = nuclear factor-KB inducing …

May 26, 2016- Explore timfluenze's board "Pathophysiology Flowcharts" on Pinterest. See more ideas about Sepsis, Septic shock and Sepsis pathophysiology. THE PATHOPHYSIOLOGY OF SEPSIS THE SEPSIS 6 ONGOING CARE SPECIAL PATIENT GROUPS MICROBIOLOGY HUMAN FACTORS AFTER SEPSIS - SURVIVOR ISSUES UK & GLOBAL POLITICS 06 12 30 40 54 80 86 93 100 104 108. 7 THE BURDEN OF SEPSIS AND SEVERE INFECTION Accurate record keeping is a vital part of good clinical practice. What we write

THE PATHOPHYSIOLOGY OF SEPSIS THE SEPSIS 6 ONGOING CARE SPECIAL PATIENT GROUPS MICROBIOLOGY HUMAN FACTORS AFTER SEPSIS - SURVIVOR ISSUES UK & GLOBAL POLITICS 06 12 30 40 54 80 86 93 100 104 108. 7 THE BURDEN OF SEPSIS AND SEVERE INFECTION Accurate record keeping is a vital part of good clinical practice. What we write Sepsis: Immune System Meltdown Pathophysiology of Sepsis Triggering Infections. Sepsis does not arise on its own. It stems from another medical condition, such as an infection in the lungs, urinary tract, skin, abdomen (eg, appendicitis) or other part of the body.

Aug 27, 2019 · Sepsis is the body’s extreme response to an infection. It is a life-threatening medical emergency. Sepsis happens when an infection you already have —in your skin, lungs, urinary tract, or somewhere else—triggers a chain reaction throughout your body. Without timely treatment, sepsis can Feb 27, 2017 · Pathophysiology of Sepsis Love our videos? Sign up for the Mastering Sepsis Webinar, Register at the link below! https://app.webinarjam.net/register/33438/01...

May 24, 2017 · Sepsis and septic shock have a mortality rate of one in every four people and often can cause permanent disability in its survivors (Dellinger et al. 2013). The vastness of this number means the cost of sepsis is not only great in regards to mortality, but also on an economic and social scale. Apr 05, 2019 · OVERVIEW Organisms Bacteria-> Gram +ve’ cocci (staphylococci, streptococci)-> Gram –ve bacilli (E.coli, Klebsiella, Pseudomonas aeruginosa) Fungi (Candida) Viruses Parasites Complex interaction between inciting microbe host immune response inflammatory pathway coagulation pathway LPS = lipopolysaccharideTRAF6 = TNF receptor-associated factor 6NIK = nuclear factor-KB inducing …

Severe Sepsis Pathophysiology Diagnosis and Treatment. In septic patients, there is a combination of apoptotic and necrotic cell death. The importance of apoptosis in the pathophysiology of sepsis has been demonstrated in multiple studies. 65 It has been shown transfer of apoptotic splenocytes will worsen survival in a mouse model of sepsis, whereas transfer of necrotic splenocytes improves, In this case study, the pathophysiology of sepsis will be discussed and the mechanism of synchronised intermittent mandatory ventilation (SIMV) volume control ventilation mode will be explained. Sepsis is defined as the dysregulated inflammatory response caused by severe infection (Neviere 2015)..

Sepsis The evolution in definition pathophysiology and

pathophysiology of sepsis pdf

» Urosepsis – Treatment Pathophysiology Symptoms Causes. Pathophysiology• Understanding the pathophysiology of sepsis has led to the development of sepsis protocols, which have proven to reduce mortality and length of hospital stay when appropriate treatment is initiated early (Lopez-Bushneil, Demaray, & Jaco, 2014). …, Request PDF on ResearchGate Pathophysiology of Sepsis Sepsis remains a critical problem with significant morbidity and mortality even in the modern era of critical care management. Multiple.

Acute kidney injury from sepsis current concepts

pathophysiology of sepsis pdf

What is sepsis? Sepsis CDC. Nov 09, 2017 · This is video 1 of 2 on shock (the types of shock & shock treatment) and sepsis and is part of the "MedCram Remastered" series: A video we've re … https://en.wikipedia.org/wiki/Systemic_inflammatory_response_syndrome pathophysiology of sepsis apoptosis in sepsis definitions host defence mechanisms inflammatory mediators innate & acquired immunity oxygen delivery in sepsis - DO2 is supranormal in septic shock mainly as a result of the elevated cardiac output - VO2 is also raised due to an increase in tissue metabolic activity.

pathophysiology of sepsis pdf

  • Sepsis pathophysiology and clinical management The BMJ
  • The Pathogenesis of Sepsis
  • pathophysiology of sepsis LITFL

  • In this case study, the pathophysiology of sepsis will be discussed and the mechanism of synchronised intermittent mandatory ventilation (SIMV) volume control ventilation mode will be explained. Sepsis is defined as the dysregulated inflammatory response caused by severe infection (Neviere 2015). Sepsis has become a major health economic issue, with more patients dying in hospitals due to sepsis related complications compared to breast and colorectal cancer together. Despite extensive research in order to improve outcome in sepsis over the last few decades, results of large multicenter studies were by-and-large very disappointing. This fiasco can be explained by several factors, but

    Aug 27, 2019 · Sepsis is the body’s extreme response to an infection. It is a life-threatening medical emergency. Sepsis happens when an infection you already have —in your skin, lungs, urinary tract, or somewhere else—triggers a chain reaction throughout your body. Without timely treatment, sepsis can Title: Sepsis: Etiology, pathophysiology and survival 1 Sepsis Etiology, pathophysiology and survival . Michelle Harkins, MD; 2 Objectives. Define the spectrum of disease from SIRS to septic shock ; Review the epidemiology and factors that effect the severity of disease ; Outline the pathophysiology of sepsis ; Discuss treatment guidelines for

    Aug 27, 2019 · Sepsis is the body’s extreme response to an infection. It is a life-threatening medical emergency. Sepsis happens when an infection you already have —in your skin, lungs, urinary tract, or somewhere else—triggers a chain reaction throughout your body. Without timely treatment, sepsis can Sepsis, systemic inflammatory condition that occurs as a complication of infection and in severe cases may be associated with acute and life-threatening organ dysfunction. Sepsis is a common cause of illness and mortality in hospitals. Learn more about the causes, symptoms, and treatment of sepsis.

    Request PDF on ResearchGate Pathophysiology of Sepsis Sepsis remains a critical problem with significant morbidity and mortality even in the modern era of critical care management. Multiple In this case study, the pathophysiology of sepsis will be discussed and the mechanism of synchronised intermittent mandatory ventilation (SIMV) volume control ventilation mode will be explained. Sepsis is defined as the dysregulated inflammatory response caused by severe infection (Neviere 2015).

    Nov 09, 2017 · This is video 1 of 2 on shock (the types of shock & shock treatment) and sepsis and is part of the "MedCram Remastered" series: A video we've re … Jan 11, 2019 · Sepsis is defined as life-threatening organ dysfunction due to dysregulated host response to infection, and organ dysfunction is defined as an acute change in total Sequential Organ Failure Assessment (SOFA) score of 2 points or greater secondary to the infection cause. [] Septic shock occurs in a subset of patients with sepsis and comprises of an underlying circulatory and cellular/metabolic

    Few pathogens cause sepsis. The majority of sepsis causing bacteria is facultative anaerobes. This type of respiration is the most flexible and it facilitates pathogen survival, proliferation and dissemination in human tissues and blood. Other conditions for causing sepsis are … Mar 17, 2017 · The resulting losses to society in terms of financial burden, morbidity, and mortality are enormous. We provide a review of sepsis, its underlying pathophysiology, and guidance for diagnosis and management of this common disease.

    Jul 01, 2003В В· PDF. Community child health, public health, and epidemiology. and the pathophysiology underlying both meningococcal septicaemia and meningitis. This increased understanding has resulted in improved management of the disorder, and is likely to lead to the introduction of new forms of treatment Most patients with meningococcal sepsis show Mar 17, 2017В В· The resulting losses to society in terms of financial burden, morbidity, and mortality are enormous. We provide a review of sepsis, its underlying pathophysiology, and guidance for diagnosis and management of this common disease.

    Sepsis Pathophysiology LITFL

    pathophysiology of sepsis pdf

    Pathophysiology of cardiovascular dysfunction in sepsis. Mortality rates for sepsis and septic shock have not improved in the past decade. The Surviving Sepsis Campaign (SSC) guidelines released in 2012 emphasize early recognition and treatment of sepsis, in an effort to reduce the burden of sepsis worldwide., PDF There has been a significant evolution in the definition and management of sepsis over the last three decades. This is driven in part due to the advances made in our understanding of its.

    Severe Sepsis Pathophysiology Diagnosis and Treatment

    Sepsis and Septic Shock Critical Care Medicine - Merck. Two major consensus conferences have defined sepsis. The first, in 1992, put forth the concept of the Systemic Inflammatory Response Syndrome (SIRS), recognizing that lethally altered pathophysiology could be present without positive blood cultures. 4 The SIRS criteria are listed in Table 1.Some clarification concerning terminology will assist the reader in this review., Sepsis is still a leading cause of hospital admissions and often leads to death if not identified early and treated properly (Pilcher, Cooper & Bellomo, 2015). In the US there are approximately 200,000 deaths annually due to sepsis (Puskarich, Illich, & Jones, 2014). It is important for advance practice nurses to recognize risk factors for sepsis..

    Mar 21, 2019 · Over the years, our understanding of the complex pathophysiology of sepsis has improved, and so has our ability to define sepsis. The word sepsis is derived from the Greek word for “decomposition” or “decay,” and its first documented use was about 2700 years ago in Homer’s poems. Feb 27, 2017 · Pathophysiology of Sepsis Love our videos? Sign up for the Mastering Sepsis Webinar, Register at the link below! https://app.webinarjam.net/register/33438/01...

    Jun 13, 2019В В· Neonatal sepsis may be categorized as early onset (day of life 0-3) or late onset (day of life 4 or later). Of newborns with early-onset sepsis, 85% present within 24 hours (median age of onset 6 hours), 5% present at 24-48 hours, and a smaller percentage present within 48-72 hours. Sepsis: Immune System Meltdown Pathophysiology of Sepsis Triggering Infections. Sepsis does not arise on its own. It stems from another medical condition, such as an infection in the lungs, urinary tract, skin, abdomen (eg, appendicitis) or other part of the body.

    Pathophysiology of Urosepsis. UTI is an infection that occurs anywhere in the urinary tract. This condition usually causes difficult or painful urination accompanied with burning sensations in the urethra. The infection can ascend to the upper urinary tract, such as in the bladder, ureters, and kidneys. May 23, 2016 · Sepsis, severe sepsis, and septic shock represent increasingly severe systemic inflammatory responses to infection. Sepsis is common in the aging population, and it disproportionately affects patients with cancer and underlying immunosuppression. In its most severe form, sepsis causes multiple organ dysfunction that can produce a state of chronic critical illness characterized by severe …

    Apr 05, 2019 · OVERVIEW Organisms Bacteria-> Gram +ve’ cocci (staphylococci, streptococci)-> Gram –ve bacilli (E.coli, Klebsiella, Pseudomonas aeruginosa) Fungi (Candida) Viruses Parasites Complex interaction between inciting microbe host immune response inflammatory pathway coagulation pathway LPS = lipopolysaccharideTRAF6 = TNF receptor-associated factor 6NIK = nuclear factor-KB inducing … Jun 08, 2015 · Sepsis is a common condition with a high mortality, which can also lead to severe sepsis and shock. This review will look at the physiological disruption of the cardiovascular system and the reflexes which occur during sepsis.

    Jun 13, 2019В В· Neonatal sepsis may be categorized as early onset (day of life 0-3) or late onset (day of life 4 or later). Of newborns with early-onset sepsis, 85% present within 24 hours (median age of onset 6 hours), 5% present at 24-48 hours, and a smaller percentage present within 48-72 hours. Oct 18, 2019В В· MODS is frequently associated with sepsis and severe sepsis. Effective therapy is essential since it is the cumulative burden of sequential organ systems that leads to death in sepsis. Respiratory failure occurs early and often in sepsis, and tends to persist.

    Jan 11, 2019 · Sepsis is defined as life-threatening organ dysfunction due to dysregulated host response to infection, and organ dysfunction is defined as an acute change in total Sequential Organ Failure Assessment (SOFA) score of 2 points or greater secondary to the infection cause. [] Septic shock occurs in a subset of patients with sepsis and comprises of an underlying circulatory and cellular/metabolic Sepsis is a serious clinical condition that represents a patient’s response to a severe infection and has a very high mortality rate. Normal immune and physiologic responses eradicate pathogens, and the pathophysiology of sepsis is due to the inappropriate regulation of these normal reactions.

    Pathophysiology of Urosepsis. UTI is an infection that occurs anywhere in the urinary tract. This condition usually causes difficult or painful urination accompanied with burning sensations in the urethra. The infection can ascend to the upper urinary tract, such as in the bladder, ureters, and kidneys. Pathophysiology and Treatment of Septic Shock in Neonates James L. Wynn, MDa,*, Hector R. Wong, MDb Sepsis or serious infection within the first 4 weeks of life kills more than 1 million

    In septic patients, there is a combination of apoptotic and necrotic cell death. The importance of apoptosis in the pathophysiology of sepsis has been demonstrated in multiple studies. 65 It has been shown transfer of apoptotic splenocytes will worsen survival in a mouse model of sepsis, whereas transfer of necrotic splenocytes improves Jun 08, 2015В В· Sepsis is a common condition with a high mortality, which can also lead to severe sepsis and shock. This review will look at the physiological disruption of the cardiovascular system and the reflexes which occur during sepsis.

    Jan 11, 2019 · Sepsis is defined as life-threatening organ dysfunction due to dysregulated host response to infection, and organ dysfunction is defined as an acute change in total Sequential Organ Failure Assessment (SOFA) score of 2 points or greater secondary to the infection cause. [] Septic shock occurs in a subset of patients with sepsis and comprises of an underlying circulatory and cellular/metabolic Sepsis is a major challenge in hospitals, where it’s one of the leading causes of death. It's also a main reason why people are readmitted to the hospital. Sepsis occurs unpredictably and can progress rapidly. What is sepsis? What causes sepsis? Many types of microbes can …

    Oct 18, 2019В В· MODS is frequently associated with sepsis and severe sepsis. Effective therapy is essential since it is the cumulative burden of sequential organ systems that leads to death in sepsis. Respiratory failure occurs early and often in sepsis, and tends to persist. Sepsis has become a major health economic issue, with more patients dying in hospitals due to sepsis related complications compared to breast and colorectal cancer together. Despite extensive research in order to improve outcome in sepsis over the last few decades, results of large multicenter studies were by-and-large very disappointing. This fiasco can be explained by several factors, but

    Sepsis Current Definition Pathophysiology Diagnosis

    pathophysiology of sepsis pdf

    Pathophysiology of Sepsis YouTube. Nov 10, 2019 · The pathophysiology of sepsis is determined by the type, severity, and duration of the condition, and can affect the body in a multitude of ways. Sepsis is a disease known as a systemic inflammatory response syndrome (SIRS) and has several possible causes, may affect a variety of different types of human tissue, and can result in a variety of adverse outcomes if not treated correctly …, Sepsis: Immune System Meltdown Pathophysiology of Sepsis Triggering Infections. Sepsis does not arise on its own. It stems from another medical condition, such as an infection in the lungs, urinary tract, skin, abdomen (eg, appendicitis) or other part of the body..

    pathophysiology of sepsis pdf

    pathophysiology of sepsis BJA Education Oxford Academic

    pathophysiology of sepsis pdf

    What Is Sepsis? Clinical Guidelines for Nurses. PATHOPHYSIOLOGY OF SEPSIS Sepsis, sever sepsis, septic shock and multiple organ failure are complex processes that encompasses pro-inflammatory, anti-inflammatory, humoral, cellular, and circulatory involvement resulting from dysregulation of the immune response to infection (28). https://en.wikipedia.org/wiki/Shock_(circulatory) pathophysiology of sepsis apoptosis in sepsis definitions host defence mechanisms inflammatory mediators innate & acquired immunity oxygen delivery in sepsis - DO2 is supranormal in septic shock mainly as a result of the elevated cardiac output - VO2 is also raised due to an increase in tissue metabolic activity.

    pathophysiology of sepsis pdf

  • Pathophysiology of cardiovascular dysfunction in sepsis
  • What is the Pathophysiology of Sepsis? (with pictures)
  • Severe Sepsis Pathophysiology Diagnosis and Treatment

  • Pathophysiology• Understanding the pathophysiology of sepsis has led to the development of sepsis protocols, which have proven to reduce mortality and length of hospital stay when appropriate treatment is initiated early (Lopez-Bushneil, Demaray, & Jaco, 2014). … Objectives: To provide an appraisal of the evolving paradigms in the pathophysiology of sepsis and propose the evolution of a new phenotype of critically ill patients, its potential underlying mechanism, and its implications for the future of sepsis management and research. Design: Literature search using PubMed, MEDLINE, EMBASE, and Google Scholar.

    Sepsis: Immune System Meltdown Pathophysiology of Sepsis Triggering Infections. Sepsis does not arise on its own. It stems from another medical condition, such as an infection in the lungs, urinary tract, skin, abdomen (eg, appendicitis) or other part of the body. Pathophysiology of Urosepsis. UTI is an infection that occurs anywhere in the urinary tract. This condition usually causes difficult or painful urination accompanied with burning sensations in the urethra. The infection can ascend to the upper urinary tract, such as in the bladder, ureters, and kidneys.

    Sepsis is a major challenge in hospitals, where it’s one of the leading causes of death. It's also a main reason why people are readmitted to the hospital. Sepsis occurs unpredictably and can progress rapidly. What is sepsis? What causes sepsis? Many types of microbes can … In septic patients, there is a combination of apoptotic and necrotic cell death. The importance of apoptosis in the pathophysiology of sepsis has been demonstrated in multiple studies. 65 It has been shown transfer of apoptotic splenocytes will worsen survival in a mouse model of sepsis, whereas transfer of necrotic splenocytes improves

    Sepsis is a major challenge in hospitals, where it’s one of the leading causes of death. It's also a main reason why people are readmitted to the hospital. Sepsis occurs unpredictably and can progress rapidly. What is sepsis? What causes sepsis? Many types of microbes can … Sepsis: Immune System Meltdown Pathophysiology of Sepsis Triggering Infections. Sepsis does not arise on its own. It stems from another medical condition, such as an infection in the lungs, urinary tract, skin, abdomen (eg, appendicitis) or other part of the body.

    Objectives: To provide an appraisal of the evolving paradigms in the pathophysiology of sepsis and propose the evolution of a new phenotype of critically ill patients, its potential underlying mechanism, and its implications for the future of sepsis management and research. Design: Literature search using PubMed, MEDLINE, EMBASE, and Google Scholar. May 24, 2017В В· Sepsis and septic shock have a mortality rate of one in every four people and often can cause permanent disability in its survivors (Dellinger et al. 2013). The vastness of this number means the cost of sepsis is not only great in regards to mortality, but also on an economic and social scale.

    THE PATHOPHYSIOLOGY OF SEPSIS THE SEPSIS 6 ONGOING CARE SPECIAL PATIENT GROUPS MICROBIOLOGY HUMAN FACTORS AFTER SEPSIS - SURVIVOR ISSUES UK & GLOBAL POLITICS 06 12 30 40 54 80 86 93 100 104 108. 7 THE BURDEN OF SEPSIS AND SEVERE INFECTION Accurate record keeping is a vital part of good clinical practice. What we write Jun 08, 2015В В· Sepsis is a common condition with a high mortality, which can also lead to severe sepsis and shock. This review will look at the physiological disruption of the cardiovascular system and the reflexes which occur during sepsis.

    Nov 10, 2019 · The pathophysiology of sepsis is determined by the type, severity, and duration of the condition, and can affect the body in a multitude of ways. Sepsis is a disease known as a systemic inflammatory response syndrome (SIRS) and has several possible causes, may affect a variety of different types of human tissue, and can result in a variety of adverse outcomes if not treated correctly … Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment Sadudee Peerapornratana1,2,3,4, Carlos L. Manrique-Caballero1,2, Hernando Go´mez1,2 and John A. Kellum1,2 1Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh,

    Pathophysiology of Urosepsis. UTI is an infection that occurs anywhere in the urinary tract. This condition usually causes difficult or painful urination accompanied with burning sensations in the urethra. The infection can ascend to the upper urinary tract, such as in the bladder, ureters, and kidneys. Jun 13, 2019В В· Neonatal sepsis may be categorized as early onset (day of life 0-3) or late onset (day of life 4 or later). Of newborns with early-onset sepsis, 85% present within 24 hours (median age of onset 6 hours), 5% present at 24-48 hours, and a smaller percentage present within 48-72 hours.

    In septic patients, there is a combination of apoptotic and necrotic cell death. The importance of apoptosis in the pathophysiology of sepsis has been demonstrated in multiple studies. 65 It has been shown transfer of apoptotic splenocytes will worsen survival in a mouse model of sepsis, whereas transfer of necrotic splenocytes improves Sepsis is a serious clinical condition that represents a patient’s response to a severe infection and has a very high mortality rate. Normal immune and physiologic responses eradicate pathogens, and the pathophysiology of sepsis is due to the inappropriate regulation of these normal reactions.

    Mortality rates for sepsis and septic shock have not improved in the past decade. The Surviving Sepsis Campaign (SSC) guidelines released in 2012 emphasize early recognition and treatment of sepsis, in an effort to reduce the burden of sepsis worldwide. Apr 05, 2019 · OVERVIEW Organisms Bacteria-> Gram +ve’ cocci (staphylococci, streptococci)-> Gram –ve bacilli (E.coli, Klebsiella, Pseudomonas aeruginosa) Fungi (Candida) Viruses Parasites Complex interaction between inciting microbe host immune response inflammatory pathway coagulation pathway LPS = lipopolysaccharideTRAF6 = TNF receptor-associated factor 6NIK = nuclear factor-KB inducing …

    PATHOPHYSIOLOGY OF SEPSIS Sepsis, sever sepsis, septic shock and multiple organ failure are complex processes that encompasses pro-inflammatory, anti-inflammatory, humoral, cellular, and circulatory involvement resulting from dysregulation of the immune response to infection (28). PATHOPHYSIOLOGY OF SEPSIS Sepsis, sever sepsis, septic shock and multiple organ failure are complex processes that encompasses pro-inflammatory, anti-inflammatory, humoral, cellular, and circulatory involvement resulting from dysregulation of the immune response to infection (28).